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John Cronin's avatar

Hi Suman - I think these messages are intended for someone else?

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suman suhag's avatar

To engage the brain in difficult problems (which may or may not be different from intellectually stimulating - this seems a little more subjective), there are widespread networks activated. So, to really understand what regions are essential in comparison with unengaging/easy problems, you need to devise an experiment where the brain will do both things in the MRI scanner. This is what I do with the n-back task. It has two types of blocks: one, where you have to identify only when a letter is the same as the one right behind it (easy: 1-back), and one where you have to remember a string of 3 constantly-changing letters (difficult: 3-back). The 3-back takes some practice. But, when you do it properly, it’s very engaging and impossible to do anything else. When I analyse my MRI data, I design contrasts that compare this difficult condition with the easy condition. I am going to post a picture of what this looks like, just for your interest, since it answers your question exactly.

What you can tell from this picture is that there is a dominance of frontal and parietal networks (and a bit of cerebellum) involved specifically in the engaging/hard blocks of the task, compared to the easy bits of the task. The biggest (most statistically significant) cluster of activation is in the dorsolateral prefrontal cortex. In my view, this is one of the most important regions involved in doing anything engaging/difficult - making hard decisions, for example.

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